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Moonjung Jung, MD, MS
Principal Investigator
I am a physician scientist with special interests in the areas of hematopoiesis, genome maintenance, and bone marrow failure (BMF) syndromes. The overarching goal of my research is to understand disease mechanisms of bone marrow failure and develop novel therapies in these areas.
Research Interests
News
Sep 13, 2022 - Our lab received the Launch Award from Maryland Stem Cell Research Fund. Thank you all for your outstanding work!
Aug 29, 2022 - Habin Bea joins our lab as a Visiting Undergraduate student from Handong Global University, Pohang, South Korea!
May 22, 2022 - Jordan A Durmaz graduated from Johns Hopkins University. Congratulations!
Oct 18, 2021 - Haruna Choijilsuren received the Provost's Undergraduate Research Award (PURA) award from Johns Hopkins University. Congratulations!
Sep 20, 2021 - Jordan A. Durmaz joins our lab as an Undergraduate student! He is a senior at Johns Hopkins University.
Sep 1, 2021 - Jungwoo kim joins our lab as the First Visiting PhD student from Ewha Womans University, Seoul, South Korea! She received the Biomedical Global Talent Development Award by the Korean Health Industry Development Institute. Congratulations!
July 12, 2021 - Yeji Park joins our lab as the First Research Technician! She is graduated from University of Maryland.
May 17, 2021 - Haruna Choijilsuren joins our lab as the First Undergraduate student! She is a rising junior at Johns Hopkins University.
Feb 1, 2021 - The Jung lab is open at Ross Research Building at the East Baltimore Campus, Johns Hopkins University School of Medicine!
Our Team
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Alumni
1 / Jordan A. Durmaz, B.S.
Undergraduate Student
Selected Publications
2022
Jung M. A commentary on: Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/determinants-of-clonal-evolution-in-aplastic-anemia-and-paroxysmal-nocturnal-hemoglobinuria/141355/65/18/1. Accessed September 27, 2022
Jung M. Inflammation fuels bone marrow exhaustion caused by Samd9l mutation. J Clin Invest. In Press
Webster ALH,*, Sanders MA*, Patel K, Dietrich R, Noonan RJ, Lach FP, White RR, Goldfarb A, Hadi K, Edwards MM, Donovan FX, Hoogenboezem RM, Jung M, Sridhar S, Wiley TF, Fedrigo O, Tian H, Rosiene J, Heineman T, Kennedy JA, Bean L, Rosti RO, Tryon R, Gonzalez A, Rosenberg A, Luo J, Carrol T, Shroff S, Beaumont M, Velleuer E, Rastatter JC, Wells SI, Surrallés J, Bagby G, MacMillan ML, Wagner JE, Cancio M, Boulad F, Scognamiglio T, Vaughan R, Beaumont KG, Koren A, Imielinski A, Chandrasekharappa SC, Auerbach AD, Singh B, Kutler DI, Campbell PJ, Smogorzewska A. Genomic signature of Fanconi anemia DNA repair pathway deficiency in cancer. Nature. In Press. *Co-first authors
Jung M*, Ilyashov I, Park Y, Donovan F, Ramanagoudr-Bhojappa R, Keahi D, Durmaz J, Choijilsuren H, Goldfarb A, Stein M, Kim J, White R, Sridhar S, Noonan R, Wiley T, Carroll T, Lach F, Auerbach A, Miranda I, Chandrasekharappa S, Smogorzewska A*. ALDH9A1 Deficiency as a Source of Endogenous DNA Damage that Requires Repair by the Fanconi Anemia Pathway. [preprint]. 2022 May. doi: 10.1101/2022.05.26.493623. * Co-corresponding authors
2021
Choijilsuren HB, Park Y, Jung M*. Mechanisms of somatic transformation in inherited bone marrow failure syndromes. Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):390-398. doi: 10.1182/hematology.2021000271. Review. PubMed PMID: 34889377; PubMed Central PMCID: PMC8791168. * Corresponding author
Yang Z, Wu XS, Wei Y, Polyanskaya SA, Iyer SV, Jung M, Lach FP, Adelman ER, Klingbeil O, Milazzo JP, Kramer M, Demerdash OE, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Smogorzewska A, Vakoc CR. Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia. Cancer Discovery. 2021 Sep;11(9):2300-2315. doi: 10.1158/2159-8290.CD-20-1542. Epub 2021 Apr 23. PubMed PMID: 33893150; PubMed Central PMCID: PMC8419016.
Jung M*, Mehta PA*, Jiang CS, Rosti RO, Usleaman G, Correa da Rosa JM, Lach FP, Goodridge E, Auerbach AD, Davies SM, Smogorzewska A, Boulad F. Comparison of the clinical phenotype and haematological course of siblings with Fanconi anaemia. Br J Haematol. 2021 Jun;193(5):971-975. doi: 10.1111/bjh.17061. Epub 2020 Aug 31. PubMed PMID: 32866285; PubMed Central PMCID: PMC7914271. *Co-first authors
Jung M, Smogorzewska A. Endogenous formaldehyde destroys blood stem cells. Blood. 2021 Apr 15;137(15):1988-1990. doi: 10.1182/blood.2020010541. PubMed PMID: 33856442; PubMed Central PMCID: PMC8057262.
2020
Jung M*, Ramanagoudr-Bhojappa R*, van Twest S*, Rosti RO, Murphy V, Tan W, Donovan FX, Lach FP, Kimble DC, Jiang CS, Vaughan R, Mehta PA, Pierri F, Dufour C, Auerbach AD, Deans AJ, Smogorzewska A, Chandrasekharappa SC. Association of clinical severity with FANCB variant type in Fanconi anemia. Blood. 2020 Apr 30;135(18):1588-1602. doi: 10.1182/blood.2019003249. PubMed PMID: 32106311; PubMed Central PMCID: PMC7193183. *Co-first authors
2018
Jung M, Cordes S, Zou J, Yu SJ, Guitart X, Hong SG, Dang V, Kang E, Donaires FS, Hassan SA, Albitar M, Hsu AP, Holland SM, Hickstein DD, Townsley D, Dunbar CE, Winkler T. GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells. Blood Adv. 2018 Dec 11;2(23):3553-3565. doi: 10.1182/bloodadvances.2018017137. PubMed PMID: 30538114; PubMed Central PMCID: PMC6290105.
Asur RS, Kimble DC, Lach FP, Jung M, Donovan FX, Kamat A, Noonan RJ, Thomas JW, Park M, Chines P, Vlachos A, Auerbach AD, Smogorzewska A, Chandrasekharappa SC. Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype. Mol Genet Genomic Med. 2018 Jan;6(1):77-91. doi: 10.1002/mgg3.350. Epub 2017 Nov 30. PubMed PMID: 29193904; PubMed Central PMCID: PMC5823675.
2017
Schlums H*, Jung M*, Han H, Theorell J, Bigley V, Chiang SC, Allan DS, Davidson-Moncada JK, Dickinson RE, Holmes TD, Hsu AP, Townsley D, Winkler T, Wang W, Aukrust P, Nordøy I, Calvo KR, Holland SM, Collin M, Dunbar CE, Bryceson YT. Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. Blood. 2017 Apr 6;129(14):1927-1939. doi: 10.1182/blood-2016-08-734236. Epub 2017 Feb 16. PubMed PMID: 28209719; PubMed Central PMCID: PMC5383869. *Co-first authors
2015
Jung M, Dunbar CE, Winkler T. Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering. Molecular Therapy. 2015 Dec;23(12):1832-42. doi: 10.1038/mt.2015.180. Epub 2015 Oct 5. Review. PubMed PMID: 26435409; PubMed Central PMCID: PMC4700116